Chebulic acid Inhibitor

Name: Chebulic acid Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5759792
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5759792

Chebulic acid, a phenolcarboxylic acid compound isolated from Terminalia chebula, has potent anti-oxidant activity,which breaks the cross-links of proteins induced by advanced glycation end-products (AGEs) and inhibits the formation of AGEs.It has effects… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Chebulic acid, Inhibitor

Full Product Name

Chebulic acid

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

356.24

Solubility

DMSO: 260mg/mL (729.85mM)
Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C14H12O11

SMILES

OC(C[C@@H]([C@H]([C@@H](C(O)=O)O1)c(c(O)c(c(O)c2)O)c2C1=O)C(O)=O)=O

CAS Number

23725-05-5

Target & IC50

VEGFR
ROS

In Vitro

chebulic acid prevents the glycer-AGEs-induced ROS formation of LX-2 cells and collagen accumulation by ERK-phosphorylation-mediated Nrf2 nuclear translocation, which causes upregulation of antioxidant protein production[2].

Product Categories/Family for Chebulic acid, inhibitor

Angiogenesis; VEGFR; Immunology/Inflammation

Product References and Citations for Chebulic acid, inhibitor

Effects of chebulic acid on advanced glycation endproducts-induced collagen cross-links. Biol Pharm Bull. 2014;37(7):1162-7. Epub 2014 Apr 24.
Effects of chebulic acid on advanced glycation endproducts-induced collagen cross-links. Biol Pharm Bull. 2014;37(7):1162-7. Epub 2014 Apr 24.
Preventive effects of chebulic acid isolated from Terminalia chebula on advanced glycation endproduct-induced endothelial cell dysfunction.J Ethnopharmacol. 2010 Oct 5;131(3):567-74.
Koo Y C, Pyo M C, Nam M H, et al. Chebulic acid prevents hepatic fibrosis induced by advanced glycation end-products in LX-2 cell by modulating Nrf2 translocation via ERK pathway.[J]. Toxicology in Vitro, 2016, 34:8-15.
Isolation of chebulic acid from Terminalia chebula Retz. and its antioxidant effect in isolated rat hepatocytes. Arch Toxicol. 2007 Mar;81(3):211-8. Epub 2006 Aug 24.

Other Notes

Small volumes of Chebulic acid, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Chebulic acid purchase

MBS5759792 is an inhibitor targeting Chebulic acid.