Hirsuteine Inhibitor

Name: Hirsuteine Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5759831
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5759831

Hirsuteine exhibits potent neuroprotective effects against glutamate-induced HT22 cell death. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Hirsuteine, Inhibitor

Full Product Name

Hirsuteine

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

366.45

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C22H26N2O3

SMILES

CO/C=C(\[C@@H](C[C@H](c1c(CC2)c(cccc3)c3[nH]1)N2C1)[C@H]1C=C)/C(OC)=O

CAS Number

35467-43-7

Target & IC50

Dopamine Receptor

In Vitro

Hirsuteine (300nM-10microM) inhibited dopamine release evoked by 100microM nicotine in a concentration-dependent manner. Hirsuteine did not produce a parallel shift of the concentration-response relationship curve for nicotine, but reduced maximal dopamine release. Dopamine release evoked by 60 and 155mM KCl was also inhibited by Hirsuteine, but the concentration necessary for significant inhibition was higher (more than 10microM). Under whole cell voltage-clamp, Hirsuteine reversibly inhibited inward currents activated by 100microM nicotine. The current inhibition was slightly accelerated by hyperpolarization[1]

Product Categories/Family for Hirsuteine, inhibitor

GPCR/G Protein; Dopamine Receptor

Product References and Citations for Hirsuteine, inhibitor

Non-competitive antagonism by hirsuteine of nicotinic receptor-mediated dopamine release from rat pheochromocytoma cells.Jpn J Pharmacol. 1993 Apr;61(4):351-6.
Non-competitive antagonism by hirsuteine of nicotinic receptor-mediated dopamine release from rat pheochromocytoma cells.Jpn J Pharmacol. 1993 Apr;61(4):351-6.
Alkaloids from the hook-bearing branch of Uncariarhynchophylla and their neuroprotective effects against glutamate-induced HT22 cell death.J Asian Nat Prod Res. 2014;16(8):876-83.

Other Notes

Small volumes of Hirsuteine, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Hirsuteine purchase

MBS5759831 is an inhibitor targeting Hirsuteine.