Onjisaponin B Inhibitor

Name: Onjisaponin B Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5759890
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5759890

Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T alpha+/--synuclein, it may have potential therapeutic effects on Parkinson disease, Alzheimer disease… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Onjisaponin B, Inhibitor

Full Product Name

Onjisaponin B

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

1573.69

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C75H112O35

SMILES

C[C@@H]1[C@@H]([C@@H]([C@@H]([C@H](O1)O[C@@H]2[C@@H]([C@@H](O[C@@H]([C@H]2O[C@@H]3[C@@H]([C@@H]([C@@H]([C@H](O3)C)O[C@@H]4[C@@H]([C@@H]([C@@H](CO4)O[C@@H]5[C@@H]([C@@H]([C@@H]([C@H](O5)CO)O)O)O)O)O)O)O)OC(=O)[C@@]67CCC(C[C@@H]6C8=CC[C@H]9[C@](C8(CC7)CO)(CC[C@@H]1[C@]9(C[C@@H]([C@@H]([C@@]1(C)C(=O)O)O[C@@H]1[C@@H]([C@@H]([C@@H]([C@H](O1)CO)O)O)O)O)C)C)(C)C)C)OC(=O)/C=C/C1=CC=C(C=C1)OC)O)O)O

CAS Number

35906-36-6

Target & IC50

AMPK
mTOR
PGE

Product Categories/Family for Onjisaponin B, inhibitor

PI3K/Akt/mTOR signaling; AMPK; GPCR/G Protein

Product References and Citations for Onjisaponin B, inhibitor

Onjisaponin B derived from Radix Polygalae enhances autophagy and accelerates the degradation of mutant alpha+/--synuclein and huntingtin in PC-12 cells. Int J Mol Sci. 2013 Nov 15;14(11):22618-41.
Onjisaponin B derived from Radix Polygalae enhances autophagy and accelerates the degradation of mutant alpha+/--synuclein and huntingtin in PC-12 cells. Int J Mol Sci. 2013 Nov 15;14(11):22618-41.
The gastrointestinal irritation of polygala saponins and its potential mechanism in vitro and in vivo. Biomed Res Int. 2015;2015:918048.

Other Notes

Small volumes of Onjisaponin B, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Onjisaponin B purchase

MBS5759890 is an inhibitor targeting Onjisaponin B.