8-Prenylnaringenin Inhibitor

Solid. Powder

99.46%

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

340.38

<1mg/ml refers to the product slightly soluble or insoluble

C20H20O5

CC(C)=CCC1=C2O[C@@H](CC(=O)C2=C(O)C=C1O)C1=CC=C(O)C=C1

53846-50-7

Estrogen Receptor/ERR
NF-kappaB
ROS

In vitro, aggregates of buccal epithelial cells were irradiated and cultured in suspension for 11 days. 8-PN or TAM were investigated regarding their effect on cell shedding. In vivo, the lower tongue surface of mice was irradiated with graded single doses of 25 kV X-rays. The incidence, latency, and duration of the resulting mucosal ulcerations were analyzed after topical treatment with 8-PN, TAM or solvent. 8-PN or TAM prevented the volume reduction of the irradiated cell aggregates during the incubation period. This was the result of a higher residual cell number in the treated versus the untreated irradiated aggregates. In vivo, topical treatment with 8-PN or TAM significantly increased the latency of mucositis from 10.9 to 12.1 and 12.4 days respectively, while the ulcer incidence was unchanged[1]

Immunology/Inflammation; ROS