3,4-O-Isopropylidene shikimic acid Inhibitor

Name: 3,4-O-Isopropylidene shikimic acid Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5759986
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5759986

3,4-Oxo- isopropylidene-shikimic acid has significant anti-inflammatory, anti-thrombosis, antioxidant, analgesic effects, it has protective effects on experimental colitis induced by trinitrobenzenesulfonic acid in rats, probably due to an antioxidant action. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

3,4-O-Isopropylidene shikimic acid, Inhibitor

Full Product Name

3,4-O-Isopropylidene shikimic acid

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

214.2

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C10H14O5

SMILES

CC(C)(O[C@H]1[C@@H](C2)O)O[C@@H]1C=C2C(O)=O

CAS Number

183075-03-8

Target & IC50

NO Synthase
NOS
PGE

In Vitro

3,4-O-Isopropylidene shikimic acid (ISA,1-100microMol/L) effectively reduced PMN adhesion to TNF-alpha-induced HUVEC with the inhibitory rate from 17.2% to 53.5 %, and exerted no effect on PMN adhesion to normal HUVEC. Adhesion molecule ICAM-1 surface protein and mRNA expression induced by TNF-alpha (400 kU/L) were significantly inhibited by ISA. In addition, the cell viability of HUVEC was unchanged 48 h after treatment with ISA[1]

Product Categories/Family for 3,4-O-Isopropylidene shikimic acid, inhibitor

Immunology/Inflammation; GPCR/G Protein

Product References and Citations for 3,4-O-Isopropylidene shikimic acid, inhibitor

3,4-oxo-isopropylidene-shikimic acid inhibits adhesion of polymorphonuclear leukocyte to TNF-alpha-induced endothelial cells in vitro. Acta Pharmacol Sin. 2004 Feb;25(2):246-50.
3,4-oxo-isopropylidene-shikimic acid inhibits adhesion of polymorphonuclear leukocyte to TNF-alpha-induced endothelial cells in vitro. Acta Pharmacol Sin. 2004 Feb;25(2):246-50.
3,4-Oxo-isopropylidene-shikimic acid promotes adiopkine expression during murine 3T3-L1 fibroblast differentiation into adipocytesJournal of Traditional Chinese Medical Sciences, 2014,1(2):120-5.

Other Notes

Small volumes of 3,4-O-Isopropylidene shikimic acid, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

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MBS5759986 is an inhibitor targeting 3,4-O-Isopropylidene shikimic acid.