3'-Demethylnobiletin Inhibitor

Name: 3'-Demethylnobiletin Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5759992
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5759992

3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human colon cancer cells, cause cell-cycle arrest, induce apoptosis, and profoundly modulate signaling proteins related with cell… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

3'-Demethylnobiletin, Inhibitor

Full Product Name

3'-Demethylnobiletin

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

388.37

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C20H20O8

SMILES

COc(ccc(C(Oc(c(OC)c1OC)c2c(OC)c1OC)=CC2=O)c1)c1O

CAS Number

112448-39-2

Target & IC50

LDL
LOX
AP-1

In Vitro

In this study, we examined the effects of NOB metabolites, 3'-hydroxy-5,6,7,8,4'-pentamethoxyflavone (3'-demethyl-NOB,3'-Demethylnobiletin), 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone (4'-demethyl-NOB) and 3', 4'-dihydroxy-5,6,7,8,-tetramethoxyflavone (3', 4'-didemethyl-NOB) and NOB analog, tangeretin, on SRs and adhesion molecules mRNA expression. 3'-Demethyl-NOB(3'-Demethylnobiletin) significantly suppressed CD36 expression, moreover, 4'-demethyl- and 3', 4'-didemethyl-NOB significantly suppressed TPA-induced expression of SR-A and LOX-1. Further, the suppressive effects of 4'-demethyl- and 3', 4'-didemethyl-NOB on the expression of CD36 mRNA were greater extent than parent NOB. The inhibitory effects of the metabolites toward TPA-induced SR mRNA expression are partly associated with the suppression of AP-1 and NF-kappaB transcriptional activities.

Product Categories/Family for 3'-Demethylnobiletin, inhibitor

Metabolism; LDL; DNA Damage/DNA Repair

Product References and Citations for 3'-Demethylnobiletin, inhibitor

Suppressive effects of demethylated metabolites of nobiletin on phorbol ester-induced expression of scavenger receptor genes in THP-1 human monocytic cells. Biofactors. 2007;31(2):107-16.

Other Notes

Small volumes of 3'-Demethylnobiletin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for 3'-Demethylnobiletin purchase

MBS5759992 is an inhibitor targeting 3'-Demethylnobiletin.