3-Deoxysappanone B Inhibitor

Solid. Powder

98.00%

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

286.3

<1mg/ml refers to the product slightly soluble or insoluble

C16H14O5

Oc(cc1)cc(OC[C@H]2Cc(cc3)cc(O)c3O)c1C2=O

113122-54-6

NO Synthase

The tension of rat thoracic aorta rings was used to evaluated the vasorelaxant activities of four homoisoflavonoids, brazlin (1), (E)-3-(3,4-dihydroxybenzylidene)-7-hydroxychroman-4-one (2), sappanone B (3), 3-Deoxysappanone B (4). Cumulative addition of homoisoflavonoids (2, 3 and 4) (50-1000microMol x L(-1)) exhibited an acute relaxation either in endothelium-intact or endothelium-denuded rings in a concentration-dependent manner. However, this relaxation was significantly inhibited in endothelium-denuded condition and in the presence of endothelial nitric oxide synthase (eNOS) inhibitor, N(W)-nitro-L-arginine methyl ester (L-NNA, 100microMol x L(-1)), and a soluble guanylate cylcase (sGC) inhibitor, methylene blue (MB, 10microMol x L(-1)) when addition of variation homoisoflavonoids brazlin (1) (50-1000microMol x L(-1)).