5-O-Caffeoylshikimic acid Inhibitor

Solid. Powder

99.82%

Store at -20°C (powder)
Store at -80°C (solvent)

336.29

Consistent with structure

Consistent with structure

The test result is consistent with structure

<1mg/ml refers to the product slightly soluble or insoluble

C16H16O8

O[C@@H]([C@@H](CC(C(O)=O)=C1)OC(C=Cc(cc2)cc(O)c2O)=O)[C@@H]1O

73263-62-4

NO Synthase
TNF-alpha
IL Receptor

Cytotoxic activity of saponins and phenolic compounds have been described in the literature, but no reports were found on their multidrug resistance (MDR)-modulating effects on human mdr1 gene-transfected mouse lymphoma cell line. Methylprototribestin, structurally related compounds and a mixture of 3 acetylated isomers of methylprotodioscin were investigated for antiproliferative effect and modulation of drug accumulation. RESULTS: The growth inhibitory dose (ID50) of the compounds ranged from 12.64 to 20.62 mug/ml. Methylprototribestin was the most effective resistance modifier. However, methylprotodioscin, pseudoprotodioscin, prosapogenin A of dioscin, tribestin and 5-O-Caffeoylshikimic acid showed moderate MDR reversal activity. In a checkerboard method, methyloprototribestin and the mixture of the 3 acetylated isomers enhanced the antiproliferative effects on MDR cells in combination with doxorubicin. CONCLUSION: Based on these results, methylprototribestin and the mixture of the 3 acetylated isomers can be recommended for further in vivo experiments in combination with anthracyclines in human MDR-cancer xenograft transplanted mice[1]

Immunology/Inflammation; Apoptosis