Alpha-caryophyllene Inhibitor

Name: Alpha-caryophyllene Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5760117
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5760117

Alpha-humulene and trans-caryophyllene extracted from S.officinalis essential oil can inhibit tumor cell growth; they also show marked anti-inflammatory effects, probably by interfering with TNFalpha production. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Alpha-caryophyllene, Inhibitor

Full Product Name

Alpha-caryophyllene

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

204.4

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C15H24

SMILES

CC1(C)/C=C/C/C(/C)=C/CC/C(/C)=C/C1

CAS Number

6753-98-6

Target & IC50

TNF-alpha

In Vitro

S. officinalis essential oil was obtained by hydrodistillation and fractionated with column chromatography; the essential oil and its fractions were analyzed by gas chromatography (GC) coupled to mass spectrometry (MS). The cytotoxic activity was evaluated in cellular lines of breast cancer MCF-7, colon cancer HCT-116, and murine macrophage RAW264.7 cell lines by the MTT assay Results: the sub-subfraction F1.1.1 of S. officinalis essential oil containing alpha-humulene present highest activity on RAW264.7 and HCT-116 with IC(50) values of 41.9 and 77.3 mu g/ml, respectively. The sub-subfraction F1.2.1 of S. officinalis essential oil with trans-caryophyllene(Alpha-caryophyllene) showed less activity on RAW246.7 and HCT-116 with IC(50) values of 90.5 and 145.8 mu g/ml.

Product Categories/Family for Alpha-caryophyllene, inhibitor

Apoptosis; TNF

Product References and Citations for Alpha-caryophyllene, inhibitor

Cytotoxic activity of alpha-humulene and trans-caryophyllene from Salvia officinalis in animal and human tumor cellsAn. Real Acad. F., 2010, 76(3):343-56.

Other Notes

Small volumes of Alpha-caryophyllene, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Alpha-caryophyllene purchase

MBS5760117 is an inhibitor targeting Alpha-caryophyllene.