Alphitolic acid Inhibitor

Solid. Powder

98.00%

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

472.7

<1mg/ml refers to the product slightly soluble or insoluble

C30H48O4

CC(=C)[C@@H]1CC[C@@]2(CC[C@]3(C)C(CCC4[C@@]5(C)C[C@@H](O)[C@H](O)C(C)(C)C5CC[C@@]34C)C12)C(O)=O

19533-92-7

Akt
NF-kappaB
p53

The phytochemical investigation of the triterpenic fraction yielded nine triterpenic acids, ceanothic acid (1), Alphitolic acid (2), maslinic acid (3), 3- O-cis-coumaroyl Alphitolic acid (4), 3- O-trans-coumaroyl Alphitolic acid (5), 3- O-trans-coumaroyl maslinic acid (6), 3- O-cis-coumaroyl maslinic acid (7), betulinic acid (8), and oleanolic acid (9). In order to perform the quantitative determination of compounds 1- 9 in Z. jujuba fruits, an analytical method based on liquid chromatography coupled to mass spectrometry with ESI source and triple quadrupole analyzer (LC-ESI(QqQ)MS), using the very sensitive and selective mass tandem experiment called Multiple Reaction Monitoring (MRM), was developed and validated. Furthermore, the antiproliferative activity of compounds 1- 9 was determined on three different cultured cell lines, namely J774A.1, MCF7 and A459 cells[1]

Cytoskeletal Signaling; Akt; NF-kappab; Apoptosis