Artocarpin Inhibitor

Name: Artocarpin Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5760150
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5760150

Artocarpin has anti- bactericidal effect, can reduce the viability of pneumococci by a factor of >1000, without obvious harm to lung epithelial cells. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Artocarpin, Inhibitor

Full Product Name

Artocarpin

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

436.5

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C26H28O6

SMILES

CC(C)C=Cc(c(O)c(c(OC(c(ccc(O)c1)c1O)=C1CC=C(C)C)c2)C1=O)c2OC

CAS Number

7608-44-8

Target & IC50

COX
TNF-alpha
IL Receptor

In Vitro

We set out to determine whether Artocarpin has cytotoxic effects on SCC cells and whether its pharmacological activity is dependent on protein-nutrient concentration. Our results showed that treatment of HSC-1 cells (a human cutaneous SCC cell line) with Artocarpin decreased cell viability and induced cell apoptosis by increasing caspase 3/7 activity. These effects were more pronounced at low fetal bovine serum (FBS) concentrations. Artocarpin induced an increase in the level of phospho-p38 and a decrease in the levels of phospho-ERK, phospho-JNK, phospho-Akt, phospho-mTOR, and phospho-S6K. High FBS concentrations in the culture media inhibited and delayed the uptake of Artocarpin from the extracellular compartment (culture media) into the intracellular compartment, as determined by high performance liquid chromatography (HPLC) analysis[1]

Product Categories/Family for Artocarpin, inhibitor

Immunology/Inflammation; COX; Apoptosis

Product References and Citations for Artocarpin, inhibitor

Artocarpin Induces Apoptosis in Human Cutaneous Squamous Cell Carcinoma HSC-1 Cells and Its Cytotoxic Activity Is Dependent on Protein-Nutrient Concentration.Evid Based Complement Alternat Med. 2015;2015:236159.
Artocarpin Induces Apoptosis in Human Cutaneous Squamous Cell Carcinoma HSC-1 Cells and Its Cytotoxic Activity Is Dependent on Protein-Nutrient Concentration.Evid Based Complement Alternat Med. 2015;2015:236159.
Antipneumococcal activity of neuraminidase inhibiting artocarpin. Int J Med Microbiol. 2015 May;305(3):289-97.

Other Notes

Small volumes of Artocarpin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Artocarpin purchase

MBS5760150 is an inhibitor targeting Artocarpin.