Ayanin Inhibitor

Name: Ayanin Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5760159
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5760159

Ayanin has vasorelaxant activity, it also may have the potential for use in treating allergic asthma. The IC(50) value of Ayanin (quercetin-3,7,4'-O-trimethylether) is 2.2microM for inhibiting interleukin (IL)-4 production from purified basophils. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Ayanin, Inhibitor

Full Product Name

Ayanin

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

344.3

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C18H16O7

SMILES

COc(cc1O)cc(OC(c(cc2)cc(O)c2OC)=C2OC)c1C2=O

CAS Number

572-32-7

Target & IC50

P450
PARP
IL Receptor

In Vitro

Incubation of human leukemia cells with Ayanin diacetate induced G(2)-M phase cell cycle arrest and apoptosis which was prevented by the non-specific caspase inhibitor z-VAD-fmk and reduced by the overexpression of Bcl-x(L). Ayanin diacetate-induced cell death was found to be associated with: (i) loss of inner mitochondrial membrane potential, (ii) the release of cytochrome c, (iii) the activation of multiple caspases, (iv) cleavage of poly(ADP-ribose) polymerase and (v) the up-regulation of death receptors for TRAIL, DR4 and DR5. Moreover, the combined treatment with Ayanin diacetate and TRAIL amplified cell death, compared to single treatment,.

Product Categories/Family for Ayanin, inhibitor

Metabolism; P450; Chromatin/Epigenetic; Immunology/Inflammation

Product References and Citations for Ayanin, inhibitor

Ayanin diacetate-induced cell death is amplified by TRAIL in human leukemia cells. Biochem Biophys Res Commun. 2012 Nov 9;428(1):116-20.

Other Notes

Small volumes of Ayanin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Ayanin purchase

MBS5760159 is an inhibitor targeting Ayanin.