Bisabolol oxide A Inhibitor

Solid. Powder

98.00%

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

238.37

<1mg/ml refers to the product slightly soluble or insoluble

C15H26O2

CC(C)([C@H](CC1)O)O[C@]1(C)[C@@H]1CC=C(C)CC1

22567-36-8

Others

In present study, the cytotoxic effect ofmicroMolar BSBO was cytometrically examined on rat thymocytes by using appropriate fluorescent dyes. When the cells were incubated with BSBO for 24 hours, BSBO at concentrations of 30microM or more significantly increased populations of dead cells, shrunken cells, and cells with phosphatidylserine exposed on membrane surface. Both cell shrinkage and externalization of membrane phosphatidylserine are general features in an early stage of apoptosis. In addition, BSBO significantly increased population of cells containing hypodiploid DNA, and the increase was completely attenuated by Z-VAD-FMK, a pan-inhibitor for caspases, indicating an involvement of caspase activation[1]