Chrysoeriol Inhibitor

Name: Chrysoeriol Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5760228
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5760228

Chrysoeriol has antioxidant, antiinflammatory, antitumor, antimicrobial, antiviral, and free radical scavenging activities, it also shows selective bronchodilator effect. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Chrysoeriol, Inhibitor

Full Product Name

Chrysoeriol

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

300.3

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C16H12O6

SMILES

COc(cc(cc1)C(Oc2c3c(O)cc(O)c2)=CC3=O)c1O

CAS Number

491-71-4

Target & IC50

ERK
p38
Akt

In Vitro

In this study, we investigated the effect of Chrysoeriol on the proliferation of human aortic smooth muscle cells (HASMC). Chrysoeriol significantly inhibited PDGF (20ng/mL)-induced migration and [(3)H]-thymidine incorporation into DNA at concentrations of 5 and 10microM without any cytotoxicity. Chrysoeriol also blocked PDGF-stimulated dissociation of actin filament and inhibited PDGF beta-receptor (Rbeta) phosphorylation in a concentration-dependent manner. As a result, the downstream signal transduction pathways of PDGF-Rbeta, including ERK1/2, p38, and Akt phosphorylation, were also inhibited by Chrysoeriol in the same pattern[1]

Product Categories/Family for Chrysoeriol, inhibitor

MAPK; ERK; Cytoskeletal Signaling

Product References and Citations for Chrysoeriol, inhibitor

An inhibitory effect of chrysoeriol on platelet-derived growth factor (PDGF)-induced proliferation and PDGF receptor signaling in human aortic smooth muscle cells.J Pharmacol Sci. 2009 May;110(1):105-10.
An inhibitory effect of chrysoeriol on platelet-derived growth factor (PDGF)-induced proliferation and PDGF receptor signaling in human aortic smooth muscle cells.J Pharmacol Sci. 2009 May;110(1):105-10.
Inhibitory effects of chrysoeriol on DNA adduct formation with benzo[a]pyrene in MCF-7 breast cancer cells. Toxicology. 2010 Jul-Aug;274(1-3):42-8.
Chrysoeriol potently inhibits the induction of nitric oxide synthase by blocking AP-1 activation.J Biomed Sci. 2005 Dec;12(6):949-59.
Selective bronchodilatory effect of Rooibos tea (Aspalathus linearis) and its flavonoid, chrysoeriol.Eur J Nutr. 2006 Dec;45(8):463-9.

Other Notes

Small volumes of Chrysoeriol, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Chrysoeriol purchase

MBS5760228 is an inhibitor targeting Chrysoeriol.