Cycloheterophyllin Inhibitor

Name: Cycloheterophyllin Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5760275
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5760275

Cycloheterophyllin has an antioxidant effect, it is a photoprotective agent that inhibits ultraviolet A (UVA)-induced oxidative stress and damage, and could be used in the research on and prevention of skin photoaging. More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Cycloheterophyllin, Inhibitor

Full Product Name

Cycloheterophyllin

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

502.56

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C30H30O7

SMILES

C\C(C)=C/Cc1c2OC(C)(C)C=Cc2c(O)c2c1oc1-c3cc(O)c(O)cc3OC(\C=C(/C)C)c1c2=O

CAS Number

36545-53-6

Target & IC50

PKA
PKC
NADPH-oxidase

In Vitro

Extending the aforementioned investigations, in this study, human dermal fibroblasts were used to investigate the protective effect of Cycloheterophyllin against UV-induced damage. We found that Cycloheterophyllin not only significantly increased cell viability, but also attenuated the phosphorylation of MAPK after UVA exposure. Furthermore, Cycloheterophyllin could reduce hydrogen peroxide (H2O2) generation and down-regulate H2O2-induced MAPK phosphorylation. In the in vivo studies, the topical application of Cycloheterophyllin before UVA irradiation significantly decreased trans-epidermal water loss (TEWL), erythema, and blood flow rate[1]

Product Categories/Family for Cycloheterophyllin, inhibitor

GPCR/G Protein; PKA; Protein Tyrosine Kinase/RTK; Cytoskeletal Signaling; Immunology/Inflammation

Product References and Citations for Cycloheterophyllin, inhibitor

Photoprotective Effects of Cycloheterophyllin against UVA-Induced Damage and Oxidative Stress in Human Dermal Fibroblasts.PLoS One. 2016 Sep 1;11(9):e0161767.
Photoprotective Effects of Cycloheterophyllin against UVA-Induced Damage and Oxidative Stress in Human Dermal Fibroblasts.PLoS One. 2016 Sep 1;11(9):e0161767.
Novel antiplatelet constituents from formosan moraceous plants.J Nat Prod. 1996 Sep;59(9):834-8.

Other Notes

Small volumes of Cycloheterophyllin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Cycloheterophyllin purchase

MBS5760275 is an inhibitor targeting Cycloheterophyllin.