Damnacanthal Inhibitor

Name: Damnacanthal Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5760282
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5760282

Damnacanthal possesses anti-cancer, immunomodulatory, antinociceptive and anti-inflammatory actions, it can treat or prevent hepatocellular carcinoma through its inhibitory effects on the HGF/c-Met axis. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Damnacanthal, Inhibitor

Full Product Name

Damnacanthal

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

282.3

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C16H10O5

SMILES

COc(c(C=O)c(cc1C(c2c3cccc2)=O)O)c1C3=O

CAS Number

477-84-9

Target & IC50

Syk
Akt
IL Receptor

In Vitro

Here we show that damnacanthal has profound inhibitory activity on mast cell activation through this pathway. The release of the granule compounds beta-hexosaminidase and tryptase release was completely abrogated by Damnacanthal at doses that were non-toxic to mast cells. In addition, damnacanthal inhibited activation-dependent pro-inflammatory gene induction, as well as cytokine/chemokine release in response to mast cell stimulation. The mechanism underlying Damnacanthal inhibition was linked to impaired phosphorylation of Syk and Akt. Furthermore, damnacanthal inhibited mast cell activation in response to calcium ionophore A23187[1]

Product Categories/Family for Damnacanthal, inhibitor

Angiogenesis; Syk; Cytoskeletal Signaling; Immunology/Inflammation

Product References and Citations for Damnacanthal, inhibitor

Damnacanthal inhibits IgE receptor-mediated activation of mast cells.Mol Immunol. 2015 May;65(1):86-93.
Damnacanthal inhibits IgE receptor-mediated activation of mast cells.Mol Immunol. 2015 May;65(1):86-93.
Damnacanthal, a noni anthraquinone, inhibits c-Met and is a potent antitumor compound against Hep G2 human hepatocellular carcinoma cells.Damnacanthal, a noni anthraquinone, inhibits c-Met and is a potent antitumor compound against Hep G2 human hepatocellSci Rep. 2015 Jan 26;5:8021.
Immunomodulatory effects of damnacanthal isolated from roots of Morinda elliptica.Pharm Biol. 2010 Apr;48(4):446-52.

Other Notes

Small volumes of Damnacanthal, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Damnacanthal purchase

MBS5760282 is an inhibitor targeting Damnacanthal.