Dehydroeffusol Inhibitor

Solid. Powder

98.00%

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

250.3

<1mg/ml refers to the product slightly soluble or insoluble

C17H14O2

Cc(c1ccc(cc(cc2C=C)O)c2c1cc1)c1O

137319-34-7

MMP
Antifection
ERK

In this study, we explored a novel anti-gastric cancer agent from a medicinal herb named Juncus effusus and found that the active component Dehydroeffusol (DHE), a small molecular phenanthrene, effectively inhibited gastric cancer cell proliferation and tumorigenesis by inducing tumor suppressive endoplasmic reticulum (ER) stress and by triggering moderate apoptosis. Mechanistic studies revealed that DHE selectively activated the intracellular tumor suppressive stress response by promoting the overexpression of the key ER stress marker DNA damage-inducible transcript 3 (DDIT3), through upregulation of activating transcription factor 4 (ATF4). Concurrently, DHE suppressed the expression of the cell survival and ER stress marker glucose regulated protein of molecular mass 78 (GRP78) via downregulation of the transcription factor ATF6. In addition, DHE markedly activated the stress response signaling pathway MEKK4-MKK3/6-p38-DDIT3, but significantly inhibited ERK signaling[1]

Proteases/Proteasome; MMP; Microbiology&virology; MAPK