Ganoderal A Inhibitor

Solid. Powder

98.00%

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

436.68

<1mg/ml refers to the product slightly soluble or insoluble

C30H44O2

[H][C@@]12CC=C3C(=CC[C@]4(C)[C@H](CC[C@@]34C)[C@H](C)CC\C=C(/C)C=O)[C@@]1(C)CCC(=O)C2(C)C

104700-98-3

Others

We report the isolation and identification of the 26-oxygenosterols ganoderol A, ganoderol B, Ganoderal A, and ganoderic acid Y and their biological effects on cholesterol synthesis in a human hepatic cell line in vitro. We also investigated the site of inhibition in the cholesterol synthesis pathway. We found that these oxygenated sterols from G. lucidum inhibited cholesterol biosynthesis via conversion of acetate or mevalonate as a precursor of cholesterol. By incorporation of 24,25-dihydro-[24,25-3H2]lanosterol and [3-3H]lathosterol in the presence of ganoderol A, we determined that the point of inhibition of cholesterol synthesis is between lanosterol and lathosterol.