Garcinone D Inhibitor

Name: Garcinone D Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5760403
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5760403

Garcinone D shows significant cytotoxicity against the CEM-SS cell line, with IC(50) value of 3.2 microg/ml; it exhibits dose-dependent enzyme-based microsomal aromatase inhibitory activity. Garcinone D inhibits p65 activation with IC50 values of 3.2microM. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Garcinone D, Inhibitor

Full Product Name

Garcinone D

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

428.48

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C24H28O7

SMILES

CC(C)(CCc(c1c(cc2O)Oc3cc(O)c(CC=C(C)C)c(O)c3C1=O)c2OC)O

CAS Number

107390-08-9

Target & IC50

p65
NF-kappaB

In Vitro

Meanwhile, the root bark of the plant furnished six xanthones, namely alpha-mangostin (2), beta-mangostin (3), gamma-mangostin (4), Garcinone D (5), mangostanol (6), and gartanin (7). The hexane and chloroform extracts of the root bark of G. mangostana as well as the hexane extract of the stem bark were found to be active against the CEM-SS cell line. gamma-Mangostin (4) showed good activity with a very low IC(50) value of 4.7microg/ml, while alpha-mangostin (2), mangostanol (6), and Garcinone D (5) showed significant activities with IC(50) values of 5.5, 9.6, and 3.2microg/ml, respectively[1]

Product Categories/Family for Garcinone D, inhibitor

NF-kappab; NF-kappaB

Product References and Citations for Garcinone D, inhibitor

Garcinia mangostana: a source of potential anti-cancer lead compounds against CEM-SS cell line.J Asian Nat Prod Res. 2008 May-Jun;10(5-6):475-9.
Garcinia mangostana: a source of potential anti-cancer lead compounds against CEM-SS cell line.J Asian Nat Prod Res. 2008 May-Jun;10(5-6):475-9.
Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity.J Nat Prod. 2008 Jul;71(7):1161-6.

Other Notes

Small volumes of Garcinone D, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Garcinone D purchase

MBS5760403 is an inhibitor targeting Garcinone D.