Gartanin Inhibitor

Name: Gartanin Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5760406
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5760406

Gartanin is an androgen receptor degradation enhancer, it is also a potential neuroprotective agent against glutamate-induced oxidative injury partially through increasing Nrf-2-independed HO-1 and AMPK/SIRT1/PGC-1alpha+/-signaling pathways. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Gartanin, Inhibitor

Full Product Name

Gartanin

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

396.4

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C23H24O6

SMILES

CC(C)=CCc(c(O)c(CC=C(C)C)c(Oc1c2c(O)ccc1O)c1C2=O)c1O

CAS Number

33390-42-0

Target & IC50

Bcl-2
Caspase
JNK

In Vitro

The interaction of Gartanin with the ligand-binding domain was characterized using a fluorescence polarization cell-free assay and cell-based FRET assay. Western blot analysis identified modulation of ER stress markers (BiP, PERK, IRE1, and CHOP) along with androgen receptor degradation. A computation simulation was performed to identify possible orientations of Gartanin with the ligand-binding domain. Utilizing a cell-free and cell-based FRET assays Gartanin was found to interact with the ligand-binding domain through a solely antagonist interaction. Interestingly, inhibition of CHOP, a critical component of the ER stress pathway, was observed to stabilize AR[1]

Product Categories/Family for Gartanin, inhibitor

Apoptosis; BCL; MAPK

Product References and Citations for Gartanin, inhibitor

The effect of gartanin, a naturally occurring xanthone in mangosteen juice, on the mTOR pathway, autophagy, apoptosis, and the growth of human urinary bladder cancer cell lines.Nutr Cancer. 2013;65 Suppl 1:68-77.
The effect of gartanin, a naturally occurring xanthone in mangosteen juice, on the mTOR pathway, autophagy, apoptosis, and the growth of human urinary bladder cancer cell lines.Nutr Cancer. 2013;65 Suppl 1:68-77.
Gartanin induces cell cycle arrest and autophagy and suppresses migration involving PI3K/Akt/mTOR and MAPK signalling pathway in human glioma cells.J Cell Mol Med. 2017 Jan;21(1):46-57.

Other Notes

Small volumes of Gartanin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Gartanin purchase

MBS5760406 is an inhibitor targeting Gartanin.