Glycycoumarin Inhibitor

Name: Glycycoumarin Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5760431
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5760431

Glycycoumarin is an estrogen agonist, it shows moderate inhibitory effects against CYP1A2 and CYP2B6. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Glycycoumarin, Inhibitor

Full Product Name

Glycycoumarin

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

368.37

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C21H20O6

SMILES

CC(C)=CCc(c(O)cc(O1)c2C=C(c(ccc(O)c3)c3O)C1=O)c2OC

CAS Number

94805-82-0

Target & IC50

P450
JNK
Autophagy

In Vitro

The anti-liver cancer activity of GCM using both in vitro and in vivo models and found for the first time that GCM possesses a potent activity against liver cancer evidenced by cell growth inhibition and apoptosis induction in vitro and tumor reduction in vivo. Mechanistically, GCM was able to bind to and inactivate oncogenic kinase T-LAK cell-originated protein kinase (TOPK), which in turn led to activation of p53 pathway[1]

Product Categories/Family for Glycycoumarin, inhibitor

Metabolism; P450; MAPK; Autophagy

Product References and Citations for Glycycoumarin, inhibitor

Glycycoumarin exerts anti-liver cancer activity by directly targeting T-LAK cell-originated protein kinase.Oncotarget. 2016 Oct 4;7(40):65732-65743.
Glycycoumarin exerts anti-liver cancer activity by directly targeting T-LAK cell-originated protein kinase.Oncotarget. 2016 Oct 4;7(40):65732-65743.
Antioxidant and anti-inflammatory activities of six flavonoids separated from licorice.Food Chem. 2013 Nov 15;141(2):1063-71.
Anti-hepatitis C virus compounds obtained from Glycyrrhiza uralensis and other Glycyrrhiza species.Microbiol Immunol. 2014 Mar;58(3):180-7

Other Notes

Small volumes of Glycycoumarin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Glycycoumarin purchase

MBS5760431 is an inhibitor targeting Glycycoumarin.