Glycyrrhisoflavone Inhibitor

Solid. Powder

98.00%

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

354.4

<1mg/ml refers to the product slightly soluble or insoluble

C20H18O6

CC(C)=CCc1cc(C2=COc(cc(cc3O)O)c3C2=O)cc(O)c1O

116709-70-7

protein tyrosine phosphatase-1B (PTP1B): ic50
NO Synthase
MAO
Tyrosinase

In this work, an approach was developed by integrating activity index (AI), liquid chromatography - mass spectrometry (LC-MS), and nuclear magnetic resonance (NMR) to rapidly predict and identify the potential active constituents from TCM. This approach was used to discover and identify the anti-inflammatory constituents from a TCM formula, Gui-Zhi-Jia-Shao-Yao-Tang (GZJSYT). The AI results indicated that, among the 903 constituents detected in GZJSYT by LC-MS, 61 constituents with higher AI values were very likely to have anti-inflammatory activities. And eight potential active constituents of them were isolated and validated to have significant inhibitory effects against NO production on LPS-induced RAW 264.7 cell model. Among them, Glycyrrhisoflavone (836), glisoflavanone (893) and isoangustone A (902) were reported to have anti-inflammatory effects for the first time.

Immunology/Inflammation; Metabolism; Proteases/Proteasome