Gossypin Inhibitor

Name: Gossypin Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5760441
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5760441

Gossypin has antidiabetic, antioxdiant, anticonvulsant, anti-allergic, antiinflammatory, antinociceptive, cytotoxic and antibacterial activities; it inhibits the NF-kappaB activation pathway, which may explain its role in the suppression of inflammation,… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Gossypin, Inhibitor

Full Product Name

Gossypin

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

480.38

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C21H20O13

SMILES

OC[C@H]([C@H]([C@@H]([C@H]1O)O)O)O[C@H]1Oc(c(OC(c(cc1)cc(O)c1O)=C1O)c(c(O)c2)C1=O)c2O

CAS Number

652-78-8

Target & IC50

Beta Amyloid
p65
NF-kappaB

In Vitro

The antioxidant properties of Gossypin were also evaluated by cell-free assays. Gossypin was found to inhibit the oxidative neuronal damage induced by xanthine/xanthine oxidase or by a glutathione depleting agent, D,L-buthionine (S,R)-sulfoximine. In addition, Gossypin significantly attenuated the neurotoxicity induced by Abeta(25-35). Furthermore, Gossypin dramatically inhibited lipid peroxidation initiated by Fe2+ and ascorbic acid in rat brain homogenates. It also exhibited potent radical scavenging activity generated from 1,1-diphenyl-2-picrylhydrazyl[1]

Product Categories/Family for Gossypin, inhibitor

Neuroscience; Beta Amyloid; NF-kappaB; NF-kappab

Product References and Citations for Gossypin, inhibitor

Gossypin protects primary cultured rat cortical cells from oxidative stress- and beta-amyloid-induced toxicity. Arch Pharm Res. 2004 Apr;27(4):454-9.
Gossypin protects primary cultured rat cortical cells from oxidative stress- and beta-amyloid-induced toxicity. Arch Pharm Res. 2004 Apr;27(4):454-9.
Free radical scavenging activity of gossypin and nevadensin: An in-vitro evaluation. Indian Journal of Pharmacology,2008, 39(6):281-283.
Cytotoxic and antibacterial activities of gossypin.Natural Product Sciences,2007,13(4):300-303.
Inhibitory effects of gossypin on RANKL-induced osteoclast differentiation and bone resorption in murine macrophages (LB364)Faseb Journal, 2014, 28.

Other Notes

Small volumes of Gossypin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Gossypin purchase

MBS5760441 is an inhibitor targeting Gossypin.