Hamamelitannin Inhibitor

Solid. Powder

98.00%

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

484.37

<1mg/ml refers to the product slightly soluble or insoluble

C20H20O14

O[C@H](COC(=O)c1cc(O)c(O)c(O)c1)[C@@H](O)[C@](O)(COC(=O)c1cc(O)c(O)c(O)c1)C=O

469-32-9

Antifection

Previously we demonstrated that Hamamelitannin (2',5-di-O-galloyl hamamelose) in Hamamelis virginiana L. exhibits potent superoxide-anion scavenging activity. We then examined the physiological and pharmacological activities of Hamamelitannin as well as its functional homologues, gallic acid and syringic acid. The following results were obtained: (1) Hamamelitannin has a higher protective activity against cell damages induced by superoxide anions than gallic acid which is the functional moiety of Hamamelitannin. The protective activity of Hamamelitannin on murine fibroblast-damage induced by superoxide anions was found at a minimum concentration of 50microM, while the corresponding figure for gallic acid was 100microM. (2) Pre-treatment of fibroblasts with Hamamelitannin enhances cell survival. (3) The superoxide-anion scavenging activity of the compound in terms of its IC50 value (50% inhibition concentration of superoxide anion radicals generated) was evaluated by ESR spin-trapping[1]

Microbiology/Virology; Antifection