Hernandezine Inhibitor

Name: Hernandezine Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5760460
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5760460

Hernandezine, a novel AMPK activator, can inhibit LPS-induced TNFalpha+/- expression/production in human macrophage cells (THP-1 and U937 lines). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Hernandezine, Inhibitor

Full Product Name

Hernandezine

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

652.77

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C39H44N2O7

SMILES

CN1CCC2=CC(=C3C=C2[C@@H]1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)C[C@H]6C7=C(CCN6C)C(=C(C(=C7O3)OC)OC)OC)OC)OC

CAS Number

6681-13-6

Target & IC50

AMPK
TNF-alpha
ROS

In Vitro

Through screening of a large collection of purified bioactive natural products, Hernandezine was identified as a potent and selective reversing agent for ABCB1-mediated MDR in cancer cells. Experimental data demonstrated that the bisbenzylisoquinoline alkaloid Hernandezine is selective for ABCB1, effectively inhibits the transport function of ABCB1, and enhances drug-induced apoptosis in cancer cells. More importantly, Hernandezine significantly resensitizes ABCB1-overexpressing cancer cells to multiple chemotherapeutic drugs at nontoxic, nanomolar concentrations[1]

Product Categories/Family for Hernandezine, inhibitor

PI3K/Akt/mTOR signaling; AMPK; Apoptosis; Immunology/Inflammation

Product References and Citations for Hernandezine, inhibitor

Hernandezine, a Bisbenzylisoquinoline Alkaloid with Selective Inhibitory Activity against Multidrug-Resistance-Linked ATP-Binding Cassette Drug Transporter ABCB1.J Nat Prod. 2016 Aug 26;79(8):2135-42.
Hernandezine, a Bisbenzylisoquinoline Alkaloid with Selective Inhibitory Activity against Multidrug-Resistance-Linked ATP-Binding Cassette Drug Transporter ABCB1.J Nat Prod. 2016 Aug 26;79(8):2135-42.
Hernandezine, a novel AMPK activator induces autophagic cell death in drug-resistant cancers.Oncotarget. 2016 Feb 16;7(7):8090-104.

Other Notes

Small volumes of Hernandezine, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Hernandezine purchase

MBS5760460 is an inhibitor targeting Hernandezine.