Humantenirine Inhibitor

Solid. Powder

98.00%

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

370.5

<1mg/ml refers to the product slightly soluble or insoluble

C21H26N2O4

[H][C@@]12C[C@]3([C@H]4C[C@@H](\C(CN1)=C\C)[C@]2([H])CO4)C(=O)N(OC)c1cc(OC)ccc31

82375-30-2

P450

A new pregnane derivative, 12 beta-hydroxy-5 alpha-pregn-16-ene-3,20-dione, along with the known derivative 12 beta-hydroxy-pregna-4,16-diene-3,20-dione have been isolated from a MeOH extract of the stem of Gelsemium sempervirens and found to be the principal cytotoxic entities. The 13C-nmr spectra of both compounds were assigned by comparison with other pregnane analogs thereby allowing confirmation of the stereochemistry at C-5 in compound. Heteronuclear 2D correlation and selective INEPT experiments indicated the need to revise a number of 13C-nmr assignments of pregn-4,16-dien-3,20-dione.

Metabolism; P450