Hyperforin Inhibitor

Solid. Powder

98.00%

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

536.8

<1mg/ml refers to the product slightly soluble or insoluble

C35H52O4

CC(C)C([C@@]([C@](C)(CCC=C(C)C)[C@@H](CC=C(C)C)C[C@]12CC=C(C)C)(C2=O)C(O)=C(CC=C(C)C)C1=O)=O

11079-53-1

COX-1
5-HT

We demonstrate that the phloroglucinol derivative Hyperforin is not only the major lipophilic chemical constituent of the medicinal plant Hypericum perforatum (St. John's wort) but also a potent uptake inhibitor of serotonin (5-HT), dopamine (DA), noradrenaline (NA), GABA and L-Glutamate with IC50 values of about 0.05-0.10microg/ml (5-HT, NA, DA, GABA) and about 0.5microg/ml (L-glutamate) in synaptosomal preparations. Furthermore, potencies of two different hypericum extracts in two conventional pharmacological paradigms useful for the detection of antidepressants (behavioral despair, learned helplessness), closely correlate with their Hyperforin contents. In addition, most till now known neuropharmacological properties of the clinically used hypericum extracts can also be demonstrated with pure Hyperforin.

Immunology/Inflammation; COX; GPCR/G Protein