Hypophyllanthin Inhibitor

Solid. Powder

98.00%

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

430.5

<1mg/ml refers to the product slightly soluble or insoluble

C24H30O7

COC[C@@H](Cc1c2)[C@@H](COC)[C@H](c(cc3)cc(OC)c3OC)c1c1OCOc1c2OC

33676-00-5

P-gp
Calcium Channel
Potassium Channel

The activity of P-gp and MRP2 was determined in the uptake assays by monitoring the intracellular accumulation of their specific substrates (calcein acetoxymethyl ester and 5(6)-carboxy-2',7'-dichlorofluorescein diacetate, respectively) with fluorescence spectroscopy. Hypophyllanthin and phyllanthin inhibited P-gp function with comparable potencies, but neither compound affected MRP2 activity. When the lignans were washed out before addition of substrate, the inhibitory action of both compounds against P-gp function was lost. These results suggested the reversibility of the inhibition. Moreover, prolonged exposure of the Caco-2 cells to both lignans (up to 7 days) had no effect on P-gp function[1]

Membrane transporter/Ion channel; P-gp