Isosilybin A Inhibitor

Name: Isosilybin A Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5760531
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5760531

Isosilybin A is a partial PPARgamma agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6uM) and diphenolase (IC50=12.1-44.9uM) of tyrosinase. Isosilybin A shows anti-angiogenic efficacy, it has… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Isosilybin A, Inhibitor

Full Product Name

Isosilybin A

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

482.4

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C25H22O10

SMILES

COc(cc([C@H]1Oc(ccc([C@H]([C@H](C2=O)O)Oc3c2c(O)cc(O)c3)c2)c2O[C@@H]1CO)cc1)c1O

CAS Number

142796-21-2

Target & IC50

PPARgamma
ABCA1
Tyrosinase

Product Categories/Family for Isosilybin A, inhibitor

Metabolism; PPAR; Membrane transporter/Ion channel; Proteases/Proteasome

Product References and Citations for Isosilybin A, inhibitor

The effect of milk thistle (Silybum marianum) and its main flavonolignans on CYP2C8 enzyme activity in human liver microsomes.Chem Biol Interact. 2017 Jun 1;271:24-29.
The effect of milk thistle (Silybum marianum) and its main flavonolignans on CYP2C8 enzyme activity in human liver microsomes.Chem Biol Interact. 2017 Jun 1;271:24-29.
Silymarin Constituents Enhance ABCA1 Expression in THP-1 Macrophages.Molecules. 2015 Dec 31;21(1):E55.
Angiopreventive efficacy of pure flavonolignans from milk thistle extract against prostate cancer: targeting VEGF-VEGFR signaling.PLoS One. 2012;7(4):e34630.
Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostate cancer LNCaP and 22Rv1 cells.Carcinogenesis. 2007 Jul;28(7):1533-42.

Other Notes

Small volumes of Isosilybin A, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Isosilybin A purchase

MBS5760531 is an inhibitor targeting Isosilybin A.