Kaempferol 3-neohesperidoside Inhibitor

Solid. Powder

98.00%

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

594.5

<1mg/ml refers to the product slightly soluble or insoluble

C27H30O15

C[C@@H]([C@@H]([C@H]([C@H]1O)O)O)O[C@H]1O[C@H]([C@H]1O)[C@H](OC2=C(c(cc3)ccc3O)Oc(cc(cc3O)O)c3C2=O)O[C@H](CO)[C@H]1O

32602-81-6

PI3K
MEK
GSK-3

A stimulatory effect of Kaempferol 3-neohesperidoside (1) on glucose uptake (35% and 21%) was observed when the rat soleus muscle was incubated with 1 and 100nM of this flavonoid glycoside, respectively. The concentration-response curve of insulin showed a stimulatory effect at 3.5 and 7.0nM (42% and 50%) on glucose uptake when compared with the control group. The effect of Kaempferol 3-neohesperidoside on glucose uptake was completely nullified by pretreatment with LY294002, an inhibitor of phosphoinositide 3-kinase (PI3K), and RO318220, an inhibitor of protein kinase C (PKC). However, no significant change occurred on glucose uptake stimulated by Kaempferol 3-neohesperidoside when muscles were pretreated with PD98059, an inhibitor of mitogen-activated protein kinase (MEK), and cycloheximide, an inhibitor of protein synthesis. Kaempferol 3-neohesperidoside and insulin (7nM) did not show a synergistic effect on glucose uptake. Additionally, 100mg/kg of Kaempferol 3-neohesperidoside by oral gavage was able to increase glycogen content in the muscle[1]

PI3K/Akt/mTOR signaling; PI3K; MAPK