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Leptomerine Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5760579

MBS5760579 is an inhibitor targeting Leptomerine. Leptomerine (IC50 = 2.5 mM) shows potent anticholinesterasic activity. More details

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Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Leptomerine, Inhibitor
Full Product Name
Leptomerine
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
201.3
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C13H15NO
SMILES
CCCC(N(C)c1c2cccc1)=CC2=O
CAS Number
22048-97-1
Target & IC50
AChR
In Vitro
Bioactivity-guided fractionation of the ethanol stems extract afforded the isolation of six alkaloids: leiokinine A, Leptomerine, kokusaginine, skimmianine, maculine and flindersiamine. All isolated compounds were tested for acetyl cholinesterase inhibition, in vitro and displayed anticholinesterasic activity. The alkaloid Leptomerine showed the highest activity (IC50 = 2.5mM), similar to that of the reference compound galanthamine (IC50 = 1.7mM).

Product Categories/Family for Leptomerine, inhibitor

Neuroscience; AChR

Product References and Citations for Leptomerine, inhibitor

Alkaloids from stems of Esenbeckia leiocarpa Engl. (Rutaceae) as potential treatment, for Alzheimer disease.Molecules. 2010 Dec 13;15(12):9205-13.

Other Notes

Small volumes of Leptomerine, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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