Licoflavone C Inhibitor

Solid. Powder

98.00%

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

338.4

<1mg/ml refers to the product slightly soluble or insoluble

C20H18O5

CC(C)=CCc(c(OC(c(cc1)ccc1O)=C1)c(c(O)c2)C1=O)c2O

72357-31-4

Antifection

The search for cytotoxic, genotoxic and/or antimutagenic natural compounds is therefore of great relevance, especially in cancer chemotherapy. In view of this, we screened the potential genotoxicity/antigenotoxicty of Licoflavone C (LFLC) - a naturally occurring prenyl-flavone extracted from Genista ephedroides - using the micronucleus (MN) assay on stimulated and cytochalasin B-blocked human lymphocytes. LFLC did not increase the spontaneous MN level up to 600microM final concentration where a strong toxicity was seen to occur. We therefore performed an antigenotoxicity assay against the two mutagenic anticancer drugs, mitomycin C (MMC) and daunorubicin (DAU), using two non-toxic LFLC concentrations (0.1microM and 1.0microM). The MN frequencies induced by 0.025microg/ml or 0.05microg/ml DAU were significantly lowered by 45.4% or 46.6% and 41.8% or 44.8% at LFLC 0.1 and 1.0microM, respectively. After treatment with 0.085microg/ml or 0.17microg/mlmMC, we detected a reduction in genotoxicity of 35.1% or 37.0% and of 38.0% or 35.8% at LFLC 0.1 and 1.0microM, respectively[1]

Microbiology/Virology; Antifection