Liriodenine Inhibitor

Name: Liriodenine Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5760595
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5760595

Liriodenine is a potent inhibitor of topoisomerase II (EC 5.99.1.3) both in vivo and in vitro, it has antitumor, antibacterial and antifungal activities, it can suppress ventricular arrhythmias induced by myocardial ischaemia reperfusion, through inhibition… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Liriodenine, Inhibitor

Full Product Name

Liriodenine

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

275.3

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C17H9NO3

SMILES

O=C(c(cccc1)c1-c1c23)c2nccc3cc2c1OCO2

CAS Number

475-75-2

Target & IC50

p53
Caspase
Bcl-2

In Vitro

The present study therefore investigated the potential antitumor effects of Liriodenine on HEp-2 human laryngocarcinoma cells in vitro and HEp-2-implanted nude mice in vivo. Liriodenine induced significant apoptosis and inhibition of cell migration in the HEp-2 cells. Furthermore, the rate of tumor growth in the HEp-2-implanted nude mice was inhibited by the administration of Liriodenine. The potential mechanism underlying the antitumor effects of Liriodenine may result from an upregulative effect upon p53 expression, which ultimately induces cellular apoptosis. By contrast, the downregulation of p53 significantly reduced the antitumor effects of Liriodenine[1]

Product Categories/Family for Liriodenine, inhibitor

Apoptosis; p53

Product References and Citations for Liriodenine, inhibitor

Liriodenine induces the apoptosis of human laryngocarcinoma cells via the upregulation of p53 expression.Oncol Lett. 2015 Mar;9(3):1121-1127.
Liriodenine induces the apoptosis of human laryngocarcinoma cells via the upregulation of p53 expression.Oncol Lett. 2015 Mar;9(3):1121-1127.
Liriodenine, early antimicrobial defence in Annona diversifolia.Z Naturforsch C. 2011 Jul-Aug;66(7-8):377-84.

Other Notes

Small volumes of Liriodenine, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Liriodenine purchase

MBS5760595 is an inhibitor targeting Liriodenine.