Matairesinol Inhibitor

Name: Matairesinol Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5760635
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5760635

Matairesinol has radical and superoxide scavenging activities,; it also has anti-angiogenic activity by suppressing mROS signaling, can decrease hypoxia-inducible factor-1alpha+/- in hypoxic HeLa cells. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Matairesinol, Inhibitor

Full Product Name

Matairesinol

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

358.4

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C20H22O6

SMILES

COc(cc(C[C@@H](CO1)[C@@H](Cc(cc2)cc(OC)c2O)C1=O)cc1)c1O

CAS Number

580-72-3

Target & IC50

ROS
ATPase
p38

In Vitro

Here we observed that of the three tested lignan molecules, Matairesinol (MAT) was the most effective as a death receptor-sensitizing agent. MAT sensitized the androgen-dependent LNCaP cells to TRAIL-induced apoptosis both in the presence and absence of androgens. treatment with MAT markedly decreased Akt activity, which has been implicated as a key signaling mechanism in the TRAIL resistance of LNCaP prostate cancer cells. The involvement of the pathway in the MAT-mediated sensitization was shown in rescue experiments using ectopic expression of constitutively active Akt[1]

Product Categories/Family for Matairesinol, inhibitor

Immunology/Inflammation; ROS; Membrane transporter/Ion channel; MAPK

Product References and Citations for Matairesinol, inhibitor

Inhibition of Akt signaling by the lignan matairesinol sensitizes prostate cancer cells to TRAIL-induced apoptosis.Oncogene. 2010 Feb 11;29(6):898-908.
Inhibition of Akt signaling by the lignan matairesinol sensitizes prostate cancer cells to TRAIL-induced apoptosis.Oncogene. 2010 Feb 11;29(6):898-908.
Radical and superoxide scavenging activities of matairesinol and oxidized matairesinol. Biosci Biotechnol Biochem. 2006 Aug;70(8):1934-40.

Other Notes

Small volumes of Matairesinol, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Matairesinol purchase

MBS5760635 is an inhibitor targeting Matairesinol.