Methyl sinapate Inhibitor

Solid. Powder

98.00%

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

238.24

<1mg/ml refers to the product slightly soluble or insoluble

C12H14O5

COC(C=Cc(cc1OC)cc(OC)c1O)=O

20733-94-2

Others

Sister-chromatid exchanges (SCEs) induced by mitomycin C (MMC), 4-nitroquinoline-1-oxide (4NQO) or UV-light in cultured Chinese hamster ovary cells (CHO K-1 cells) were enhanced by cinoxate (2-ethoxyethyl p-methoxycinnamate) or Methyl sinapate (methyl 3,5-dimethoxy 4-hydroxycinnamate). Both substances are cinnamate derivatives and cinoxate is commonly used as a cosmetic UV absorber. Methyl sinapate also increased the frequency of cells with chromosome aberrations in the CHO K-1 cells treated withmMC, 4NQO or UV. These increasing effects of Methyl sinapate were critical in the G1 phase of the cell cycle and the decline of the frequencies of UV-induced SCEs and chromosome aberrations during liquid holding was not seen in the presence of Methyl sinapate. Both compounds were, however, ineffective in cells treated with X-rays. In cells from a normal human embryo and from a xeroderma pigmentosum (XP) patient,mMC-induced SCEs were also increased by the post-treatment with Methyl sinapate. The SCE frequencies in UV-irradiated normal human cells were elevated by Methyl sinapate, but no SCE-enhancing effects were observed in UV-irradiated XP cells.