Pinostrobin Inhibitor

Name: Pinostrobin Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5760796
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5760796

Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aalpha²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage and calcium overload, as well as suppressing the mitochondrial pathway of… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Pinostrobin, Inhibitor

Full Product Name

Pinostrobin

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

270.3

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C16H14O4

SMILES

COc1cc(O[C@@H](CC2=O)c3ccccc3)c2c(O)c1

CAS Number

480-37-5

Target & IC50

TNF-alpha
IL Receptor
Beta Amyloid

In Vitro

Pinostrobin was isolated from the dichloromethane extract of Renealmia alpinia leaves. The protective properties of the extract and of Pinostrobin against the indirect hemolytic, coagulant and proteolytic effects of Bothrops asper venom were evaluated in vitro, and the anti-hemorrhagic and anti-inflammatory activity were evaluated in vivo. Renealmia alpinia extract significantly inhibited the proteolytic activity and indirect hemolytic activity of Bothrops asper venom at a venom:extract ratio of 1:20. Moreover, the present data demonstrate that Pinostrobin may mitigate some venom-induced local tissue damage due to hemorrhagic effects, and the compound is also responsible for the analgesic and anti-inflammatory activity of the extract from Renealmia alpinia. This is the first report to describe Pinostrobin in the species Renealmia alpinia and its properties in vitro against Bothrops asper venom[1]

Product Categories/Family for Pinostrobin, inhibitor

Apoptosis; TNF; Immunology/Inflammation; Neuroscience

Product References and Citations for Pinostrobin, inhibitor

Inhibition of the toxic effects of Bothrops asper venom by pinostrobin, a flavanone isolated from Renealmia alpinia (Rottb.) MAAS.J Ethnopharmacol. 2014 Sep 29;155(3):1609-15.
Inhibition of the toxic effects of Bothrops asper venom by pinostrobin, a flavanone isolated from Renealmia alpinia (Rottb.) MAAS.J Ethnopharmacol. 2014 Sep 29;155(3):1609-15.
Protective effects of pinostrobin on beta-amyloid-induced neurotoxicity in PC12 cells.Cell Mol Neurobiol. 2012 Nov;32(8):1223-30.
Activity investigation of pinostrobin towards herpes simplex virus-1 as determined by atomic force microscopy.Phytomedicine. 2011 Jan 15;18(2-3):110-8.

Other Notes

Small volumes of Pinostrobin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Pinostrobin purchase

MBS5760796 is an inhibitor targeting Pinostrobin.