Pomolic acid Inhibitor

Solid. Powder

98.00%

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

472.7

<1mg/ml refers to the product slightly soluble or insoluble

C30H48O4

C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CCC4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@@]34C)C2[C@]1(C)O)C(O)=O

13849-91-7

HIV
Caspase
AMPK

Oleanolic acid (1) was identified as an anti-HIV principle from several plants, including Rosa woodsii (leaves), Prosopis glandulosa (leaves and twigs), Phoradendron juniperinum (whole plant), Syzygium claviflorum (leaves), Hyptis capitata (whole plant), and Ternstromia gymnanthera (aerial part). It inhibited HIV-1 replication in acutely infected H9 cells with an EC50 value of 1.7microg/mL, and inhibited H9 cell growth with an IC50 value of 21.8microg/mL [therapeutic index (T. I.) 12.8]. Pomolic acid, isolated from R. woodsii and hours. capitata, was also identified as an anti-HIV agent (EC50 1.4microg/mL, T. I. 16.6). Although ursolic acid did show anti-HIV activity (EC50 2.0microg/mL), it was slightly toxic (IC50 6.5microg/mL, T. I. 3.3). A new triterpene (11) was also isolated from the CHCl3-soluble fraction of R. woodsii, though it showed no anti-HIV activity. The structure of 11 was determined to be 1beta-hydroxy-2-oxoPomolic acid by spectral examination. Based on these results, we examined the anti-HIV activity of oleanolic acid- or Pomolic acid-related triterpenes isolated from several plants. In addition, we previously demonstrated that derivatives of betulinic acid, isolated from the leaves of S. claviflorum as an anti-HIV principle, exhibited extremely potent anti-HIV activity[1]

Microbiology/Virology; HIV Protease; Apoptosis; PI3K/Akt/mTOR signaling