Primin Inhibitor

Solid. Powder

98.00%

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

208.26

<1mg/ml refers to the product slightly soluble or insoluble

C12H16O3

CCCCCC(C(C(OC)=C1)=O)=CC1=O

15121-94-5

Antifection

Primin showed very potent activity against Trypanosoma brucei rhodesiense (IC50 0.144microM) and Leishmania donovani (IC50 0.711microM), and revealed low cytotoxicity (IC50 15.4microM) on mammalian cells. Only moderate inhibitory activity was observed against Mycobacterium tuberculosis, Trypanosoma cruzi, and Plasmodium falciparum. When tested for in vivo efficacy in a Trypanosoma b. brucei rodent model, Primin failed to cure the infection at 20mg/kg given intraperitoneally. Primin was too toxic in vivo at a higher concentration (30mg/kg, injected i.p. route) in mice infected with L. donovani.

Microbiology/Virology; Antifection