Schisantherin D Inhibitor

Name: Schisantherin D Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5760896
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5760896

Schisantherin D shows good anti-HIV activity with the EC50 value of 0.5 micrograms/mL, and the therapeutic index (TI) value of 110. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Schisantherin D, Inhibitor

Full Product Name

Schisantherin D

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

520.53

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C29H28O9

SMILES

COc1c2OCOc2cc2C[C@H](C)[C@](C)(O)[C@@H](OC(=O)c3ccccc3)c3cc4OCOc4c(OC)c3-c12

CAS Number

64917-82-4

Target & IC50

HIV

In Vitro

Seven of these compounds (1, 6, 8-12) were active as anti-HIV agents. Gomisin G (11) exhibited the most potent anti-HIV activity with EC50 and therapeutic index (TI) values of 0.006 microgram/mL and 300, respectively. Schisantherin D (6), kadsuranin (8), and schisandrin C (10) showed good activity with EC50 values of 0.5, 0.8, and 1.2 micrograms/mL, and TI values of 110, 56, and 33.3, respectively. Ten related synthetic biphenyl compounds, five variously substituted bismethylenedioxy, dimethoxy, and dimethoxycarbonyl isomers (18-22) and five brominated derivatives (23-27) also were evaluated for inhibitory activity against HIV-1 replication in acutely infected H9 cells.

Product Categories/Family for Schisantherin D, inhibitor

Microbiology/Virology; HIV Protease

Product References and Citations for Schisantherin D, inhibitor

Anti-AIDS agents--XXVI. Structure-activity correlations of gomisin-G-related anti-HIV lignans from Kadsura interior and of related synthetic analogues. Bioorg Med Chem. 1997 Aug;5(8):1715-23.

Other Notes

Small volumes of Schisantherin D, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Schisantherin D purchase

MBS5760896 is an inhibitor targeting Schisantherin D.