Sempervirine Inhibitor

Name: Sempervirine Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5760911
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5760911

Sempervirine can unwind circular DNA, it shows selective inhibition of in vitro synthesis of cancer DNA. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Sempervirine, Inhibitor

Full Product Name

Sempervirine

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

272.4

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C19H16N2

SMILES

C1CCC2=C[N+]3=C(C=C2C1)C4=C(C=C3)C5=CC=CC=C5N4

CAS Number

6882-99-1

Target & IC50

DNA/RNA Synthesis

In Vitro

The high template in vitro activity of native DNA from cancerous mammalian and plant tissues, compared to DNA from healthy tissues, enabled us to select substances which selectively inhibit cancer DNA synthesis. Among them, alstonine, serpentine, Sempervirine and flavopereirine, all alkaloids which belong to the Beta-carboline class, distinguish cancer DNA from healthy tissue DNA inhibit DNA in vitro synthesis when native DNA from different cancerous tissues or cells is used as template. They have practically no effect on DNA from healthy tissues. The inhibitory effect of alkaloids is due to their capacity to form an 'alkaloid-cancer DNA' complex which has been characterized by use of the Sephadex column.

Product Categories/Family for Sempervirine, inhibitor

DNA Damage/DNA Repair; DNA/RNA Synthesis

Product References and Citations for Sempervirine, inhibitor

Selective inhibition of in vitro synthesis of cancer DNA by alkaloids of beta-carboline class.Exp Cell Biol. 1982;50(2):79-87.

Other Notes

Small volumes of Sempervirine, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Sempervirine purchase

MBS5760911 is an inhibitor targeting Sempervirine.