Silybin B Inhibitor

Name: Silybin B Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5760920
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5760920

Silybin B and silybin A are potent inhibitors of both raloxifene 4'- and 6-glucuronidation in all enzyme systems; they show strong effects on cell growth inhibition and apoptosis induction in human chronic myeloid leukemia K562 cells. Silybin B exhibits… More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Silybin B, Inhibitor

Full Product Name

Silybin B

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

482.44

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C25H22O10

SMILES

COc(cc([C@@H]1Oc(cc([C@H]([C@H](C2=O)O)Oc3c2c(O)cc(O)c3)cc2)c2O[C@H]1CO)cc1)c1O

CAS Number

142797-34-0

Target & IC50

Calcium Channel
ROS

In Vitro

The present study assessed the effects of the diastereoisomers on cell apoptosis, and compared these with their mixture, silybin, in human chronic myeloid leukemia K562 cells. Both isomers showed stronger effects on cell growth inhibition and apoptosis induction than silybin. Compared with Silybin B, silybin A showed higher effects on the production of intracellular reactive oxygen species and Ca2+.

Product Categories/Family for Silybin B, inhibitor

Membrane transporter/Ion channel; Calcium Channel; Immunology/Inflammation

Product References and Citations for Silybin B, inhibitor

A comparison of the diastereoisomers, silybin A and silybin B, on the induction of apoptosis in K562 cells.Nat Prod Commun. 2011 Nov;6(11):1653-6.

Other Notes

Small volumes of Silybin B, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Silybin B purchase

MBS5760920 is an inhibitor targeting Silybin B.