Sophoflavescenol Inhibitor

Name: Sophoflavescenol Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5760926
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5760926

Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects, these effects might contribute to the antitumor activity without severe side effects. Sophoflavescenol… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Sophoflavescenol, Inhibitor

Full Product Name

Sophoflavescenol

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

368.4

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C21H20O6

SMILES

CC(C)=CCc(c(OC(c(cc1)ccc1O)=C1O)c(c(OC)c2)C1=O)c2O

CAS Number

216450-65-6

Target & IC50

Caspase
ROS
NF-kappaB

In Vitro

Despite the small effect on human breast adenocarcinoma (MCF-7), Sophoflavescenol showed cytotoxicity against human leukaemia (HL-60), Lewis lung carcinoma (LLC), and human lung adenocarcinoma epithelial (A549) cells. Interestingly, it also exerted potent in vivo antitumor activity by tumor growth inhibition in the LLC tumor model as well as apoptotic activity by caspase-3 activation in HL-60 cells. In addition, it exhibited potent antioxidant activities in 1,1-diphenyl-2-picrylhydrazyl, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt radicals and lipid peroxidation assays. Sophoflavescenol exerted notable anti-inflammatory activity by inhibiting nitric oxide generation and tert-butylhydroperoxide-induced ROS generation rather than inhibiting nuclear factor kappa B activation in RAW 264.7 cells[1]

Product Categories/Family for Sophoflavescenol, inhibitor

Apoptosis; Caspase; Immunology/Inflammation; NF-kappab

Product References and Citations for Sophoflavescenol, inhibitor

Anti-tumorigenic activity of sophoflavescenol against Lewis lung carcinoma in vitro and in vivo. Arch Pharm Res. 2011 Dec;34(12):2087-99.
Anti-tumorigenic activity of sophoflavescenol against Lewis lung carcinoma in vitro and in vivo. Arch Pharm Res. 2011 Dec;34(12):2087-99.
A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2313-6.

Other Notes

Small volumes of Sophoflavescenol, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Sophoflavescenol purchase

MBS5760926 is an inhibitor targeting Sophoflavescenol.