Sotetsuflavone Inhibitor

Solid. Powder

98.00%

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

552.5

<1mg/ml refers to the product slightly soluble or insoluble

C31H20O10

COc(cc1O)c(-c(cc(cc2)C(Oc3c4c(O)cc(O)c3)=CC4=O)c2O)c(OC(c(cc2)ccc2O)=C2)c1C2=O

2608-21-1

Others

Herein we describe the structure-activity relationship study of 23 compounds: biflavonoids from D. balansae (1-4) and from D. araucarioides (5-10), hexamethyl-amentoflavone (11), cupressuflavone (12), and apigenin derivatives (13-23). We conclude that 1) over the four different biflavonoid skeletons tested, amentoflavone (1) and robustaflavone (5) are the most promising ones for antidengue drug development, 2) the number and position of methyl groups on the biflavonoid moiety modulate their inhibition of Dengue virus NS5 RNA-dependent RNA polymerase, and 3) the degree of oxygenation of flavonoid monomers influences their antidengue potential.