1-Hydroxy-2,3,5-trimethoxyxanthone Inhibitor

1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independent mechanism by inhibiting Ca(2+) influx through L-type voltage-operated Ca(2+) channels; a minor contribution to the effects of HM-1 may be related to inhibition of the protein kinase C-mediated release of intracellular Ca(2+) stores. HM-1,at the concentration of 1ug/mL, can effectively inhibit the osteoclast differentiation in a co-culture system with mouse osteoblastic calvarial cells and bone marrow cells; it also can protect mice from the acute lung injury induced by ipopolysaccharide (LPS), which is relative to the increasing of IkappaB-alpha protein expression and the suppressing of inducible nitric oxide synthase and cyclooxygenase-II protein expression.

Mechanisms of the vasorelaxant effect of 1-hydroxy-2, 3, 5-trimethoxy-xanthone, isolated from a Tibetan herb, Halenia elliptica, on rat coronary artery. Life Sci. 2007 Sep 1;81(12):1016-23
Inhibitors of bone resorption from Halenia corniculata. Arch Pharm Res. 2008 Jul;31(7):850-5.

Small volumes of 1-Hydroxy-2,3,5-trimethoxyxanthone, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5761179 is an inhibitor targeting 1-Hydroxy-2,3,5-trimethoxyxanthone.