Asebogenin Inhibitor

Asebogenin has anti-bacterial activity, it shows inhibitory activity against S. aureus and methicillin-resistant S. aureus (IC50 of 10 and 4.5 micrograms/ml, respectively); it shows antiplasmodial activities against both a chloroquine-sensitive and a resistant strain of Plasmodium falciparum. Asebogenin can inhibit the proliferation of murine B cells.

Anti-secretory, anti-inflammatory and anti-Helicobacter pylori activities of several fractions isolated from Piper carpunya Ruiz & Pav. J Ethnopharmacol. 2010 Apr 21;128(3):583-9.
Dihydrochalcones from Piper longicaudatum. Planta Med. 2001 Mar;67(2):186-8.
The in vitro antiplasmodial activities of 14 plant species traditionally used in Central America for the treatment,of malaria or fever were evaluated. Lipophilic extracts of Piper hispidum, Siparuna andina, S. pauciflora, S. tonduziana, and Xylopia cf. fr. Trop Med Int Health. 1999 Sep;4(9):611-5.

Small volumes of Asebogenin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5761917 is an inhibitor targeting Asebogenin.