Dalbergioidin Inhibitor

Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces bikiniensis that has commonly been used as an indicator organism. Dalbergioidin protects MC3T3-E1 osteoblastic cells against H2O2-induced cell damage through activation of the PI3K/AKT/SMAD1 pathway, suggests that it may be useful in bone metabolism diseases, particularly osteoporosis. Dalbergioidin also ameliorates doxorubicin-induced renal fibrosis by suppressing the TGF-beta signal pathway.

Human neutrophil elastase inhibitory potential of flavonoids from Campylotropis hirtella and their kinetics. J Enzyme Inhib Med Chem. 2016;31(sup1):16-22.

Small volumes of Dalbergioidin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5762159 is an inhibitor targeting Dalbergioidin.