Grifolin Inhibitor

Grifolin has anti-cancer effects, it induces apoptosis and promotes cell cycle arrest in the A2780 human ovarian cancer cell line via inactivation of the ERK1/2 and Akt pathways; it enhances the differentiation and proliferation of oligodendrocyte precursor cells (OPCs) in oxygen/glucose deprivation (OGD)-induced injury by altering the expressions of Id2 and Olig2. Grifolin possesses antimicrobial activities against Bacillus cereus and Enterococcus faecalis, it also shows antifungal activity against plant pathogenic fungi (Erysiphe graminis). Grifolin exhibits in vitro antileishmanial activity. Grifolin shows hypocholesterolemic action on rats fed with a High-cholesterol diet.

Grifolin Attenuates White Matter Lesion in Oxygen/Glucose Deprivation. Transl Neurosci. 2017 Oct 15;8:102-110.
Grifolin inhibits tumor cells adhesion and migration via suppressing interplay between PGC1alpha and Fra-1/LSF- MMP2/CD44 axes. Oncotarget. 2016 Oct 18;7(42):68708-68720.
Antibacterial compounds from mushrooms I: a lanostane-type triterpene and prenylphenol derivatives from Jahnoporus hirtus and Albatrellus flettii and their activities against Bacillus cereus and Enterococcus faecalis. Planta Med. 2010 Feb;76(2):182-5.

Small volumes of Grifolin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5762486 is an inhibitor targeting Grifolin.