Murrangatin Inhibitor

Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the high viability of Raji cells, it also exhibits cytotoxicity against cholangiocarcinoma cell line, KKU-100. Murrangatin exhibits antibacterial activity against P. gingivalis ( 33277). Murrangatin also shows soluble epoxide hydrolase inhibitory activity with IC50 values 13.9+/-6.5uM. Murrangatin and murracarpin may be a new backbone for developing inhibitors of cyclooxygenase 2, they show chondroprotective activity by downregulation of interleukin-1beta, tumor necrosis factoralpha, prostaglandins E2, and matrix metalloproteinases -13, and both of them may be a new backbone for developing inhibitors of cyclooxygenase 2.

Chondroprotective evaluation of two natural coumarins: murrangatin and murracarpin. J. Intercult.Ethnopharmacol.,2013; 2(2):91-8.
Anti-tumor-promoting effects of 8-substituted 7-methoxycoumarins on Epstein-Barr virus activation assay. Cancer Lett. 1999 Apr 26;138(1-2):87-92.
Coumarins and flavonoid from Murraya paniculata (L.) Jack: Antibacterial and anti-inflammation activity. Pak J Pharm Sci. 2015 Nov;28(6):1947-51.

Small volumes of Murrangatin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5762798 is an inhibitor targeting Murrangatin.