Nortrachelogenin Inhibitor

Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth factor receptors, thereby efficiently synergizing with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), exposure.Nortrachelogenin has anti-inflammatory properties,it shows moderate inhibiting activities on NF- kappaB signaling pathway induced by TNF-alpha, with the IC50 value of 49.4uM. Nortrachelogenin also shows anti-plasmodium activity of 14.50 dg/ml. (+)-Nortrachelogenin shows effects on the central nervous system producing depression in rabbits, it is moderately active against HIV-1 in vitro. (-)-Nortrachelogenin exerts its antibacterial effect by disorganizing and perturbing the cytoplasmic membrane, it also can induce membrane disruption and caspase-dependent apoptosis.

Anti-plasmodial activity of Nortrachelogenin from the root bark of Carissa edulis (vahl) Int. J. Appl. Res.Nat.Prod.,2011,4(3):755-6.
(-)-Nortrachelogenin from Partrinia scabiosaefolia elicits an apoptotic response in Candida albicans. FEMS Yeast Res. 2016 May;16(3).
Antibacterial Mechanism of (-)-Nortrachelogenin in Escherichia coli O157. Curr Microbiol. 2016 Jan;72(1):48-54.
Antifungal, antimitotic and anti-HIV-1 agents from the roots of Wikstroemia indica. Planta Med. 2000 Aug;66(6):564-7.

Small volumes of Nortrachelogenin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5762864 is an inhibitor targeting Nortrachelogenin.