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N-FORMYL-MET-LEU-PHE-LYS Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5763455

N-Formyl-Met-Leu-Phe-Lys (fMLFK) is a peptide, acts as a potent and selective agonist of FPR1, with EC50s of 3.5nM, 6.7 uM and 0.88 uM for FPR1, FPR2 and FPR2-D2817.32G, respectively.Chemotactic peptide (fMLFK) binds specifically to receptors on leukocyte… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
N-Formyl-Met-Leu-Phe-Lys, Inhibitor
Full Product Name
N-Formyl-Met-Leu-Phe-Lys
Product Gene Name
N-Formyl-Met-Leu-Phe-Lys, inhibitor
Product Synonym Names
fMLFK
Form/Format
Solid. Powder
Purity/Purification
99.70%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
565.73
Solubility
H2O: Soluble
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C27H43N5O6S
CAS Number
67247-11-4
Target & IC50
FPR1: ic50 3.5nM (EC50)
FPR2: ic50 6.7uM (EC50)
FPR2-D2817.32G: ic50 0.88uM (EC50)

Structure of N-Formyl-Met-Leu-Phe-Lys, inhibitor

N-FORMYL-MET-LEU-PHE-LYS Inhibitor – Cat# MBS5763455

Product References and Citations for N-Formyl-Met-Leu-Phe-Lys, inhibitor

He HQ, et al. Structural determinants for the interaction of formyl peptide receptor 2 with peptide ligands. J Biol Chem. 2014 Jan 24;289(4):2295-306.
Chen LY, et al. Synergistic induction of inflammation by bacterial products lipopolysaccharide and fMLP: an important microbial pathogenic mechanism. J Immunol. 2009 Feb 15;182(4):2518-24.
Hetland G, et al. Chemotaxins C5a and fMLP induce release of calprotectin (leucocyte L1 protein) from polymorphonuclear cells in vitro. Mol Pathol. 1998 Jun;51(3):143-8.

Other Notes

Small volumes of N-Formyl-Met-Leu-Phe-Lys, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for N-Formyl-Met-Leu-Phe-Lys purchase

MBS5763455 is an inhibitor targeting N-Formyl-Met-Leu-Phe-Lys.
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